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Hello dog breeders, in this video I explain unusual inheritance of "hairlessness" in the Mexican "Hairless dog", or Xoloitzcuintle, - this breed characterized by a sparse hair coat. This phenotype is a consequence of Canine Ectodermal Dysplasia (CED) caused by a mutation on the FoxI3 autosomal gene. First accounts of hairless dogs in Mexico are dated to the 16th century CE, according to the historical record, but pre-Hispanic dog skeletons presenting missing and abnormally shaped teeth have been interpreted as earlier evidence of hairless dogs. However, several questions remain unanswered regarding the timing of apparition of this phenotype and its relationship with modern hairless breeds.
